Precision Treatment of Recurrent/Metastatic Salivary Gland Carcinoma Guided by Molecular Typing
Recruiting
Phase 2Interventional Study
Salivary Gland CarcinomaPrecision Therapy
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 100
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
39 (estimated)
Sponsor
Peking Union Medical College · Other
Who this trial is looking for
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Patients with salivary gland carcinoma were divided into groups according to HER2, NTRK, AR, TROP-2, etc. Patients in different groups were given precision targeted therapy or chemotherapy to evaluate the efficacy (ORR rate) and safety of precision therapy.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients with histopathologic diagnosis of salivary gland carcinoma
* The tumor tissues were subjected to HER2/NTRK/AR/TROP-2 immunohistochemical staining.
* ECOG physical status 0 or 1 score in the 3 days before the first medication of the study treatment;
* Ag…
Inclusion Criteria:
* Patients with histopathologic diagnosis of salivary gland carcinoma
* The tumor tissues were subjected to HER2/NTRK/AR/TROP-2 immunohistochemical staining.
* ECOG physical status 0 or 1 score in the 3 days before the first medication of the study treatment;
* Age 18 or older - no upper limit;
* Life expectancy is more than 3 months; ⑥Have at least one measurable lesion according to RECIST1.1 standards; ⑦Women of childbearing age must have a negative pregnancy test within 7 days before the first medication, and agree to receive the necessary contraceptive measures;
⑧The patient must have adequate liver, kidney, bone marrow, heart and lung and other organ functions:
⑨Understanding and voluntarily signing informed consent prior to performing any research-related evaluation/operation;
⑩Ability to comply with research visit schedules and other programmatic requirements.
Exclusion Criteria:
* Known hypersensitivity or delayed anaphylaxis to any agents in this trial;
* Major surgery had been performed within 4 weeks prior to the start of the study and did not fully recover;
* Have received a live vaccine within 4 weeks before the start of the study or plan to receive any vaccine during the study period ;
* To study the occurrence of arterial/venous thrombosis events within 6 months before medication;
* Major cardiovascular diseases;
* Is suffering from uncontrolled systemic diseases, including diabetes, hypertension, pulmonary fibrosis, acute lung disease, interstitial lung disease, cirrhosis, etc.;
* Is suffering from an active infection that requires systemic treatment;
* History of active tuberculosis; ⑨ Positive human immunodeficiency virus (HIV) test result; ⑩ Patients with chronic hepatitis B or active hepatitis C. ⑪Conditions that the investigator believes will affect the safety or compliance of the drug therapy in this study ⑫Female/male who is pregnant or breastfeeding or who intends to give birth;
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