No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
300 (estimated)
Sponsor
Perminder Sachdev · Other
Who this trial is looking for
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The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL). This study will examine the clinical features and longitudinal course of CADASIL. Outcome measures include neuropsychological profile, neuroimaging, genetics, blood biomarkers, and retinal imaging.
Trial Locations
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Facility
City
State
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Status
Eligibility Criteria
Inclusion criteria:
1. Adults ≥18 years old
2. Ability to provide written informed consent
* A large-print version is available for individuals with visual impairment
* An easy-to-read version is available for individuals with cognitive difficulties who may require extra support
3. Ability t…
Inclusion criteria:
1. Adults ≥18 years old
2. Ability to provide written informed consent
* A large-print version is available for individuals with visual impairment
* An easy-to-read version is available for individuals with cognitive difficulties who may require extra support
3. Ability to attend a testing site
4. Ability to complete minimum dataset (medical examination and medical history questionnaire, blood test to determine genetic status and a short (20 minute) neuropsychology assessment).
5. CADASIL participants according to one of the following categories:
1. confirmed diagnosis via genetic testing (NOTCH3 pathogenic variant), OR
2. suspected diagnosis based on medical history and brain MRI, OR
3. first degree relative of participant who is positive for NOTCH3 pathogenic variant
OR 6. Unrelated individual who is negative for the NOTCH3 pathogenic variant, and has no cognitive complaints (i.e. control participant)
Exclusion criteria:
1\. Significant cognitive impairment leading to an inability to provide informed consent.
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