A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
Recruiting
Phase 3
Interventional Study
Coarctation of Aorta
High Blood Pressure
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Supportive Care
- Participants needed
- 120 (estimated)
- Sponsor
- Mayo Clinic · Other
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About This Trial
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* B/S1 hypertension
* SBP 100-139 average based on 3 office measurements.
* Age 18 or Older
* Previous COA Repair
Exclusion Criteria:
* Currently on beta blocker (BB) therapy
* Pregnancy/lactating
* eGFR\<30
* Hyperkalemia (serum potassium \>5.5mmol/L)
* Severe Aortic or Mitra…
Contacts