Study on the Improvement of Myocardial Microcirculation After Acute Anterior Myocardial Infarction

Inclusion Criteria: Clinical Inclusion Criteria: 1. Subjects aged ≥18 years; 2. Initial diagnosis of anterior wall ST-segment elevation myocardial infarction, with symptoms occurring within 6 hours, and undergoing primarypercutaneous coronary intervention (PCI); 3. Subjects (or legal representatives) who understand the study requirements and treatment procedures and provide signed informed consent. Imaging Inclusion Criteria (Visual Estimation): 1. Target lesion is the culprit lesion, located in the native coronary artery, with a visually estimated reference vessel diameter (RVD) between 2.25 mm and 4.0 mm; 2. Culprit segment of the infarct-related artery (IRA) is located between the origin of the left anterior descending (LAD) artery and the emergence of the second diagonal branch (D2); 3. After pre-treatment , the degree of stenosis in the LAD is ≤90%, and TIMI flow is grade 3. Exclusion Criteria: Clinical Exclusion Criteria: 1. History of coronary artery bypass grafting (CABG); 2. Known history of myocardial infarction or PCI; 3. Previous thrombolytic therapy before PCI; 4. Severe liver or kidney dysfunction, severe valvular heart disease, chronic obstructive pulmonary disease, etc.; 5. Contraindications to magnetic resonance imaging; 6. Allergy to gadolinium contrast agents and/or accompanying medications for devices or procedures (e.g., any component of drug-eluting stents, all P2Y12 inhibitors, or aspirin); 7. Expected lifespan of the subject less than 12 months; 8. Pregnant or lactating females; 9. Other subjects deemed unsuitable for participation in the study by the investigator. Imaging Exclusion Criteria (Visual Estimation): 1. Presence of lesions requiring intervention other than the target lesion at baseline surgery; 2. No protected left main coronary artery disease (visual estimate of stenosis \>50%); 3. Diffuse severe calcification (\>20 mm) or chronic total occlusion in the major coronary vessels (LCX, RCA); 4. Severe coronary artery tortuosity (\>45°) or calcification (\>270°), or other conditions that may interfere with the use of intravascular imaging.