A Pilot Study to Evaluate the Systemic Effect of Oral Supplementation With AM3 in Patients With Metabolic Syndrome.

Inclusion Criteria: 1. Men or women aged 18-75 years at the time of signing the informed consent form. 2. Diagnosis of metabolic syndrome, defined as: central obesity, elevation of blood glucose by ≥100 mg/dl, glycosylated hemoglobin between 5.7 and 6.4%, low HDL cholesterol levels \< 40 mg/dl in men and \< 50 mg/dl in women, and high levels of triglycerides, being higher than 150 mg/dl. 3. If the patient is being treated with metformin, lipid-lowering treatment with statins or treatment with antihypertensives, he/she must have a stable dose at the time of inclusion. Exclusion Criteria: 1. Smokers or with history of alcoholism or drug abuse . 2. To have hypertriglyceridemia (\> 500 mg/dL). 3. Uncontrolled arterial hypertension, as per investigator's criteria. 4. To have undergone bariatric surgery over the last 24 months that according to investigator's criteria, this might interfere with his/her participation in the study. 5. Diagnosis of chronic diseases that according to investigator's criteria, this might interfere with his/her participation in the study. 6. Presence of renal insufficiency (glomerular filtration rate below 30 ml/minute). 7. Presence of severe respiratory insufficiency (PaO2 less than 60 mmHg or PaCO2 greater than 50 mmHg). 8. Presence of heart failure (LVEF \<30% and RVEF \<35%). 9. Presence of the following diseases in an unstable manner, according to the investigator's criteria: chronic obstructive disease, inflammatory bowel disease, intestinal malabsorption syndrome, systemic autoimmune diseases, rheumatoid arthritis, spondyloarthritis, psoriasis, and chronic inflammatory skin diseases. 10. Active or chronic severe unstable infections that, in medical criteria, may interfere with patients' safety. 11. Disease-related malnutrition. 12. Endocrinologic unestable or uncontrolled diseases that in medical criteria, present with manifestations in pituitary, adrenal or thyroid function. 13. Immunosuppressive or corticosteroid treatment in the last 3 months. 14. Treatment with semaglutide and tirzepatide. 15. Pregnant women (or intending to become pregnant) or breast-feeding women.