Prophylactic Antibiotics in Cystectomy With Diversion
Recruiting
Early Phase 1
Interventional Study
Muscle-Invasive Bladder Carcinoma
Radical Cystectomy
Ileal Conduit
Neobladder Diversion
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 120 (estimated)
- Sponsor
- University of Minnesota · Other
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About This Trial
Using a randomized 2 arm design, this study is being conducted to test for non-inferiority of no prophylactic antibiotic therapy versus the prophylactic oral antibiotic, nitrofurantoin, through comparison of rates of postoperative urinary tract infections within the 90-day postoperative period in patients with muscle invasive bladder cancer who undergo radical cystectomy with urinary diversion.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Presence of muscle invasive bladder cancer and planning to undergo radical cystectomy with either ileal conduit or neobladder diversion.
* 18 years of age or older
Exclusion Criteria:
* Currently receiving antimicrobials for active infection
* Poor renal function with GFR \<…
Contacts