Electroacupuncture for the Prevention of Chemotherapy-induced Nausea and Vomiting in Patients With Breast Cancer

Inclusion Criteria: 1. Aged 18 years or older and aged 75 years or younger, of any nationality; 2. Eastern Cooperative Oncology Group performance status of 0-2; 3. Patients with breast cancer, with no restrictions on molecular typing; early-stage patients must not have undergone prior chemotherapy, while advanced-stage patients must be candidates for first-line chemotherapy and have declined neoadjuvant or adjuvant chemotherapy for over 3 months. All patients must receive highly emetogenic chemotherapy (HEC) based on anthracycline chemotherapy with cyclophosphamide (EC or AC) or carboplatin (AUC≥4)/cisplatin; 4. Predicted life expectancy of ≥3 months; 5. Adequate bone marrow, kidney, and liver function; 6. Adequate contraception if premenopausal women; 7. Written informed consent by the patient before enrolment. Exclusion Criteria: 1. Patients already submitted to chemotherapy; 2. Is scheduled to receive any non-HEC on Day 1; 3. Is scheduled to receive any chemotherapy on days 2-4 after HEC; 4. Received or is scheduled to receive radiation therapy to the abdomen, pelvis, head and neck within 1 week prior to Day 1 or between Days 1 to 5 in cycle 1; 5. Has symptomatic primary or metastatic symptomatic central nervous system malignancy causing nausea and/or vomiting; 6. Have ongoing emesis or CTCAE grade 2 or greater nausea; 7. Significant medical or mental conditions; 8. Any allergies to study drug, antiemetics or dexamethasone; 9. Significantly abnormal laboratory values (platelets, coagulation indexes, absolute neutrophils, AST, ALT, bilirubin or creatinine); 10. Patients who are pregnant or breast-feeding; 11. Inflammatory skin reaction; 12. Has lymphedema in acupuncture stimulation area; 13. Patients who are afraid of electroacupuncture stimulation or allergic to stainless steel needles; 14. Received acupuncture treatments for any conditions less than 4 weeks before HEC; 15. Currently using drugs with antiemetic activity (e.g., 5-HT3 receptor antagonists, corticosteroids (except when used at physiological doses), dopamine receptor antagonists, minor tranquilizers, antihistamines, and benzodiazepines (except for nocturnal sedation)); 16. Patients with concomitant severe diseases or with a predisposition to emesis such as gastrointestinal obstruction, active peptic ulcer, and hypercalcemia and symptomatic brain metastasis; 17. Has a convulsive disorder requiring anticonvulsant treatment; 18. Patients administered thioridazine as a chronic antipsychotic medication (patients are allowed to receive prochlorperazine and other phenothiazines as a rescue antiemetic treatment); 19. Concurrent treatment with quinolone antibiotics; 20. Has a history of chronic alcoholism (determined by the investigator); 21. Known arrhythmias, uncontrolled congestive heart failure, or acute myocardial infarction within the past six months; 22. Has a history of uncontrolled diabetes (e.g., using insulin or oral hypoglycemic agents).