No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Other
Participants needed
31 (estimated)
Sponsor
Stanford University · Other
Who this trial is looking for
This trial is looking for people with knee osteoarthritis to see if a special training can help change how their calf muscles work while walking. Participants will receive feedback on their muscle activation during walking sessions in a lab or outside.
Are You a Good Fit for This Trial?
You may be able to join if
I have medial and/or lateral compartment knee osteoarthritis
I have been diagnosed with knee osteoarthritis for at least six months
I can walk without aids
I can walk for at least 60 minutes
I usually rate my pain as 1-4 on a scale of 0-10
I can reduce my gastrocnemius muscle activation by 10% from baseline
You may not be able to join if
I have a history of arthritis in lower limb joints other than my knees
I have had any lower extremity joint replaced
I have symptoms from my patellofemoral joint
My body mass index is 35 or greater
I have a nerve or muscle disease that makes walking difficult
I have a history of rheumatoid arthritis, gout, or autoimmune disease
I have had a lower limb fracture or surgery that needed hospitalization
I am pregnant
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading.
Prior research has utilized musculoskeletal simulations to determine that reducing the activation of one of the calf muscles, the gastrocnemius, can have a large impact on reducing knee loa…
This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading.
Prior research has utilized musculoskeletal simulations to determine that reducing the activation of one of the calf muscles, the gastrocnemius, can have a large impact on reducing knee loading. However, this has not been tested in individuals with knee osteoarthritis. In this study, participants will be trained to alter the activation of their gastrocnemius muscle, by receiving haptic feedback after each step. The feedback will indicate how the participant changed their muscle activation relative to baseline. Some participants will train on a treadmill in the laboratory for up to two sessions, with 30 minutes of walking with feedback in each session. If a participant can learn to adjust their muscle activation in the first training session, they will be able to complete the second training session. Other participants will train outside the laboratory for one session with 30 minutes of walking with feedback to investigate changes in knee loading while using the new walking strategy during over-ground walking.
The movement data collected during the training sessions will be used as inputs to computer simulations of the musculoskeletal system to determine if walking with the new muscle activation strategy reduces knee loading.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Medial and/or lateral compartment knee osteoarthritis
* Diagnosed with knee osteoarthritis of at least six months duration
* Ambulatory without aids
* Able to walk for at least 60 minutes
* Typical pain rating of 1-4 on scale of 0-10
* Able to reduce gastrocnemius muscle activ…
Inclusion Criteria:
* Medial and/or lateral compartment knee osteoarthritis
* Diagnosed with knee osteoarthritis of at least six months duration
* Ambulatory without aids
* Able to walk for at least 60 minutes
* Typical pain rating of 1-4 on scale of 0-10
* Able to reduce gastrocnemius muscle activation by 10% from baseline
Exclusion Criteria:
* History of symptomatic arthritis in lower limb joints other than the knees
* Replacement of any lower extremity joint
* Symptoms originating from the patellofemoral joint
* Body mass index equal to or greater than 35
* Nerve or muscle disease associated with walking difficulty
* History of rheumatoid arthritis, gout, or autoimmune disease
* History of lower limb fracture or surgery requiring hospitalization
* Pregnant
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.