CC-99282 + Rituximab Early Post CART for Non-Hodgkin's Lymphoma

Recruiting Phase 1 Interventional Study
B-Cell Non-Hodgkin Lymphoma-Recurrent Diffuse Large B-Cell Lymphoma-Recurrent Follicular Lymphoma-Recurrent High Grade B-Cell Lymphoma-Recurrent Primary Mediastinal Large B-Cell Lymphoma-Recurrent Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma-Recurrent B-Cell Non-Hodgkin Lymphoma-Refractory Diffuse Large B-Cell Lymphoma-Refractory Follicular Lymphoma-Refractory High Grade B-Cell Lymphoma-Refractory Primary Mediastinal Large B-Cell Lymphoma-Refractory Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma-Refractory
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
18 (estimated)
Sponsor
Nathan Denlinger · Other
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About This Trial
This phase I trial tests the safety, side effects and best dose of CC-99282 with rituximab for the treatment of patients who have received chimeric antigen receptor (CAR) T cell therapy for non-Hodgkins lymphoma and in whom have had a sub-optimal response early on to CAR T-cell therapy. Immunotherapy with CC-99282 may induce changes in the body's immune system and may interfere with the ability of…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Written informed consent obtained to participate in the study and Health Insurance Portability and Accountability Act (HIPAA) authorization for release of personal health information * Age ≥ 18 years at the time of consent * Diagnosis of B-cell Non-Hodgkin's lymphoma including…
Contacts

The Ohio State Comprehensive Cancer Center

800-293-5066

OSUCCCClinicaltrials@osumc.edu

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