Testing Health Workers At Risk to Advance Our Understanding of TB Infection

Recruiting Observational Study
Tuberculosis Tuberculosis Infection
No Placebo Group Every participant receives an active treatment — no one gets a placebo. No Study Drug Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 – 100
Sex
Any
Study type
Observational
Participants needed
300 (estimated)
Sponsor
Beth Israel Deaconess Medical Center · Other
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About This Trial
It has been estimated that 1.7 billion people have tuberculosis (TB) infection; yet current tests are unable to predict which people are at highest risk of developing TB disease, which can be life-threatening. THWART-TB is a prospective longitudinal cohort study of health workers (HWs) in Cape Town, South Africa, where our preliminary data reveals HWs have a high annual TB infection risk (34%). Th…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * ≥18 years old * Health worker * Able to provide informed consent Exclusion Criteria: * Prior history of TB or known prior positive IGRA * Current or prior history of taking anti-TB treatment
Contacts

Ruvandhi Nathavitharana, MBBS MPH

+16467152601

rnathavi@bidmc.harvard.edu

CONTACT

Grant Theron, PhD

+27 21 9389693

gtheron@sun.ac.za

CONTACT