Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
Recruiting
N/AInterventional Study
Cognitive DeclineCognitive Impairment
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
40 – 75
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
88 (estimated)
Sponsor
Ohio State University · Other
Who this trial is looking for
This trial is looking for adults who feel their thinking or memory is getting worse and have a higher body weight. Participants will eat one study snack each day for a week to see how it affects their thinking after meals.
Are You a Good Fit for This Trial?
Rules you outDiabetesCancerGastrointestinal diseasesHyperthyroidismFood allergiesSevere kidney failureLiver cirrhosis
You may be able to join if
I have subjective cognitive impairment.
I have a body mass index (BMI) of 30 or more.
My HbA1C level is less than 6.5%.
You may not be able to join if
I have been diagnosed with cognitive impairment or dementia.
My Montreal Cognitive Assessment (MoCA) score is below 26.
I have current or previous diabetes or take diabetes medications.
I am being treated for cancer (except non-melanoma skin cancer).
I have gastrointestinal diseases that affect food intake.
I have hyperthyroidism.
I have food allergies or intolerances.
I cannot provide a vein for blood tests.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Subjective cognitive impairment
* BMI ≥30 kg/m2
* HbA1C \<6.5%
Exclusion Criteria:
* Diagnosis og cognitive impairment or dementia
* Montreal Cognitive Assessment (MoCA) score of \<26
* Current or previous diagnosis of Diabetes or use of diabetes medications
* Current diagno…
Inclusion Criteria:
* Subjective cognitive impairment
* BMI ≥30 kg/m2
* HbA1C \<6.5%
Exclusion Criteria:
* Diagnosis og cognitive impairment or dementia
* Montreal Cognitive Assessment (MoCA) score of \<26
* Current or previous diagnosis of Diabetes or use of diabetes medications
* Current diagnosis of or current treatment of cancer other than non-melanoma skin cancer
* Gastrointestinal diseases or disorders (including pancreatic and gastric bypass surgery) where consumption of the study foods would be contraindication or where the disease or disorder could negatively affect nutrient absorption and/or would prevent participants from tolerating the study foods
* Hyperthyroidism diagnosis
* Food Allergy or intolerances
* Any dietary restriction where consumption of the study foods, study meals/snack or meal challenge or any ingredient would be contraindicated
* Use of some oil supplements in the past 4 weeks prior to enrolling
* Pregnancy and lactation
* Inability to access veins for venipuncture
* Antibiotic use in the past month
* Psychostimulant or nootropic medication use
* Current use of supplements or medications for weight loss or following a weight loss program
* Severe or uncontrolled autoimmune diseases
* Current or previous diagnosis of severe kidney failure, liver cirrhosis and some pulmonary diseases
* Heart disease events (including stroke or heart attack) within last 3 months prior to enrollment
* Alcohol or drug abuse
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