Ketones, SGLT2, HFrEF

Recruiting Early Phase 1 Interventional Study
Type2diabetes Heart Failure With Reduced Ejection Fraction
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At a Glance
Age
18 – 70
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Basic Science
Participants needed
71 (estimated)
Sponsor
The University of Texas Health Science Center at San Antonio · Other
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About This Trial

The study team will examine the effects of elevated plasma ketone levels following initiation of SGLT2 inhibitor therapy in high-risk type 2 diabetes mellitus (T2DM) individuals with heart failure (HF) with reduced ejection fraction (HFrEF) providing an energy-rich fuel that is taken up with great avidity by the myocardium, to measure change in Left Ventricle diastolic and systolic function

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Type 2 Diabetes Mellitus * Class II-III New York Heart Association (NYHA) heart failure and reduced ejection fraction (EF) \<50% * Age 18-80 years * BMI 23-44 kg/m2 * Glycated hemoglobin (HbA1c) 6.0-10.0% * Blood Pressure (BP) ≤ 145/85 mmHg * Estimated glomerular filtration ra…
Contacts

Ralph DeFronzo, MD

210-567-6691

defronzo@uthscsa.edu

CONTACT

Sivaram Neppala, MD

210-358-7200

neppalas@uthscsa.edu

CONTACT