A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation

Recruiting N/A Interventional Study
Posttraumatic Stress Disorder
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At a Glance
Age
18 – 60
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
120 (estimated)
Sponsor
University of Pennsylvania · Other
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About This Trial
This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with exti…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Adult aged 18-60 * Meets Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for PTSD according to the Clinician-Administered PTSD Scale for DSM-5 * No metal implants Exclusion Criteria: * Pregnancy * Seizure disorder or epilepsy * Increased risk of seizur…
Contacts

Lily A Brown, PhD

2157463346

lilybr@pennmedicine.upenn.edu

CONTACT