Combined taVNS and tDCS in Subacute Stroke Patients

Inclusion Criteria: * Age ≥ 18 years old * Subacute ischemic stroke patients within 7-30 days after stroke symptoms is stabilized * Stroke will be documented by DWI-MRI * Lesion locations at least involve supratentorial area * Patients have unilateral weakness documented with manual muscle testing scales less than 4 * Stable vital signs and stable neurological signs * Able to receive regular rehabilitation programs, and 8) modified Rankin Scales (mRS) less than 5. Exclusion Criteria: * A National Institute of Health Stroke Scale (NIHSS) score \> 25 at study entry * The presence of hemineglect * Moderate-to-severe pain in any limb * Unstable clinical condition * Recurrent strokes or brainstem strokes * Marked arrhythmia or cardiovascular complications * Bradycardia (HR≤50 bpm) or low blood pressure (SBP≤100 mmHg or DBP≤60mmHg) at admission * Patients with radiographic evidence or suspicion of chronic conditions that may predispose them to intracranial hemorrhage including brain arteriovenous malformations, cerebral cavernous malformations, cerebral telangiectasia, multiple previous intracerebral hemorrhages (amyloid angiopathy) * Pre-existing coagulopathy, consist of platelet count of ≤100, INR≥ 3, PTT≥ 90 * Patients suspected of having infective endocarditis and ischemic stroke related to septic emboli * Signs or symptoms of acute myocardial infarction, including EKG findings * Concomitant experimental therapy * Suspected cerebral vasculitis based on medical history and CTA/Magnetic Resonance Angiogram (MRA) * Suspected cranial dural arteriovenous fistula, and evidence of dissection in the intracranial cerebral arteries * Cerebral venous thrombosis and significant mass effect with midline shift * History of left atrial myxoma * Presence of contraindication for VNS (TENS) and tDCS: (A) Intracranial space occupied lesion, (B) Presence of a pacemaker, (C) History of brain neurosurgery, (D) Active CNS or systemic infection, (E) Presence of a metallic foreign body implant, (F) Skin abnormalities, (G) History of alcohol/drug abuse, (H) Epilepsy/History of epilepsy at family (I) Hyperacusis, (J) Cognitive/Consciousness disturbance, (K) Pregnancy or nursing females, (L) Use of neuropsycoactive drugs, (M) Psychiatric/ Neurologic disease * Not suitable for equipping ECG recorders: (A) Chronic disease, and allergic to polyester, (B) Acute and severe patients