Neoadjuvant Immunochemotherapy for Oral Cancer

Inclusion Criteria: 1. Eastern Cooperative Oncology Group (ECOG) performance status (PS): 0-1 2. Histopathological diagnosis of oral squamous cell carcinoma (including tongue, gums, cheek, floor of mouth, hard palate, and posterior molar region) 3. Primary tumor with a clinical stage of III/IVA (T1-2/N1-2/M0 or T3-4a/cN0-2/M0, AJCC 2018) 4. Patients must have at least one measurable lesion according to the Response Evaluation Criteria in Solid Tumors (RECIST v1.1) 5. Blood routine: white blood cells (WBCs) \>3,000/mm3, hemoglobin \>8 g/L, platelets \>80,000/mm3 6. Liver function: alanine amino transferase/aspartate amino transferase (ALAT/ASAT) \<2.5 times the upper limit of normal and bilirubin \<1.5 times the upper limit of normal 7. Renal function: Serum creatinine \<1.5 times the upper limit of normal 8. Coagulation function: INR、PT、APTT\<1.5 times the upper limit of normal 9. Signed the informed consent form Exclusion Criteria: 1. Unresolved grade 2 \[(Common Terminology Criteria for Adverse Events (CTCAE 5.0)\] or higher toxic reactions caused by previous anticancer treatments 2. Known allergic reaction (grade 3-4) to any ingredients or excipients of the therapy 3. Known history of malignancy, unless been cured and no recurrence for 5 years 4. Known history of radiation to head and neck 5. Active severe clinical infection (\> National Cancer Institute (NCI)-CTCAE version 5.0 grade 2 infection) 6. Obvious cardiovascular abnormalities \[such as myocardial infarction, superior vena cava syndrome, grade 2 or higher heart disease diagnosed according to the New York Heart Association (NYHA) classification 3 months before enrollment\] 7. Patients receiving immunology-based treatment for any reason 8. Patients with a history of active bleeding, coagulopathy, or receiving coumarin anticoagulation therapy 9. Pregnant or lactating women 10. Known active hepatitis B or C. Active hepatitis B is defined as a known HBsA positive with HBV DNA≥500 IU/mL. Active hepatitis C is defined as a known hepatitis C antibody positive and a known amount of hepatitis C virus HCV RNA results greater than the lower limit of detection. The presence of other serious liver diseases, including chronic autoimmune liver disease, primary biliary cirrhosis or sclerosing cholangitis, alcoholic liver disease, or non-alcoholic steatohepatitis (NASH) 11. Complicated with severe, uncontrolled infection or known human immunodeficiency virus (HIV) infection, or diagnosed as acquired immunodeficiency syndrome (AIDS); or uncontrolled autoimmune disease; or history of allogeneic tissue/organ transplantation, stem cell or bone marrow transplantation, or solid organ transplantation 12. Participation in other clinical trials within 30 days before enrollment 13. Other situations that the investigator considers unsuitable with respect to participating in the trial