Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)
Recruiting
N/AInterventional Study
Hiv
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
200 (estimated)
Sponsor
Johns Hopkins University · Other
Who this trial is looking for
This trial is looking for patients with HIV who need a kidney transplant. Participants will help researchers understand kidney rejection when receiving transplants from donors with or without HIV.
Are You a Good Fit for This Trial?
You may be able to join if
I need a kidney transplant.
I can understand and agree to participate.
I have been diagnosed with HIV.
I am at least 18 years old.
My HIV-1 RNA is below 50 copies/mL.
I do not have significant wasting related to HIV.
You may not be able to join if
I have had progressive multifocal leukoencephalopathy.
I have had cryptosporidiosis for more than 1 month.
I have had primary central nervous system lymphoma.
I am pregnant or breastfeeding.
I have other medical problems that could complicate my participation.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Participant meets local criteria for kidney transplant.
* Participant is able to understand and provide informed consent.
* Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA.
* Participant is ≥ 18 years old.
* HIV-1 RN…
Inclusion Criteria:
* Participant meets local criteria for kidney transplant.
* Participant is able to understand and provide informed consent.
* Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA.
* Participant is ≥ 18 years old.
* HIV-1 RNA \< 50 copies/mL. Viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements \> 200 copies/mL.
* Participant is not suffering from significant wasting (e.g. body mass index \<21) thought to be related to HIV disease.
Exclusion Criteria:
* Participant has prior progressive multifocal leukoencephalopathy (PML), cryptosporidiosis of \> 1 month, or primary central nervous system (CNS) lymphoma.
* Participant is pregnant or breastfeeding.
* Past or current medical problems or findings from medical history, physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.
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