No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
40 and older
Sex
Female
Study type
Observational
Participants needed
1,000 (estimated)
Sponsor
University of British Columbia · Other
Who this trial is looking for
This trial is looking for women aged 40 and older who have unexplained abnormal bleeding and need an endometrial biopsy. Participants will answer health questions and some will collect vaginal samples for testing.
Are You a Good Fit for This Trial?
Rules you outEndometrial cancerEndometrial intraepithelial neoplasiaRecommended for hysterectomy
You may be able to join if
I am 40 years or older
I have unexplained abnormal uterine bleeding
I have an intact uterus
I have been referred for an endometrial biopsy
You may not be able to join if
I have had endometrial sampling, pelvic radiation, or a vaginal infection in the past 3 months
I started hormone therapy in the past year, except for tamoxifen
I have had intercourse, used vaginal products, or douched in the past 48 hours
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The study goal is to investigate a non-invasive approach to predict endometrial cancer (EC) risk, better understand disease progression and identify opportunities for intervention.
This two-part case-cohort prospective study will recruit patients whose abnormal uterine bleeding is being evaluated via endometrial biopsy. Participants will complete an online health questionnaire, and a subset will …
The study goal is to investigate a non-invasive approach to predict endometrial cancer (EC) risk, better understand disease progression and identify opportunities for intervention.
This two-part case-cohort prospective study will recruit patients whose abnormal uterine bleeding is being evaluated via endometrial biopsy. Participants will complete an online health questionnaire, and a subset will be invited to self-collect vaginal samples for sequencing.
Selected sequenced participants will be invited for longitudinal monitoring (questionnaires, wearable fitness tracker) and an additional vaginal self-collection to identify persistent genetic mutations or microbiome alterations 6-8 months later.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
Study Part A:
* 40 years and older
* Experiencing unexplained abnormal uterine bleeding (i.e., not from IUD, etc.)
* Have an intact uterus
* Referred for an endometrial biopsy
Study Part B/Longitudinal monitoring:
* Those selected for sequencing (from Part A) and who retained…
Inclusion Criteria:
Study Part A:
* 40 years and older
* Experiencing unexplained abnormal uterine bleeding (i.e., not from IUD, etc.)
* Have an intact uterus
* Referred for an endometrial biopsy
Study Part B/Longitudinal monitoring:
* Those selected for sequencing (from Part A) and who retained their uterus.
Exclusion Criteria:
Study Part A:
* Endometrial sampling, pelvic radiation, or vaginal infection (vaginosis, yeast) in the past 3 months
* Started hormone therapy (HRT, birth control, IUD) in the past year (with the exception of tamoxifen)
* Intercourse, vaginal product use, or douching in the past 48 hours
Study Part B/Longitudinal monitoring:
* Same as Study Part A
* EC or EIN, or anyone who is recommended a hysterectomy
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