Trazodone on OSA Endotypes
Recruiting
Phase 1
Phase 2
Interventional Study
Obstructive Sleep Apnea
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 21 – 70
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 18 (estimated)
- Sponsor
- Brigham and Women's Hospital · Other
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About This Trial
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for spontaneous upper airway (UA) dilator muscle recruitment. As a consequence they are exposed to apnea and hypopnea cycling. In this protocol the investigators will test the e…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Moderate-to-severe OSA (AHI ≥ 15 events/hr)
Exclusion Criteria:
* All participants will be healthy and without major organ system disease that would preclude undergoing the physiological measurements.
* Use of medications expected to stimulate or depress respiration (includi…
Contacts