French Assessment of MRD by Liquid Biopsies in Stage III CRC Patients (FRENCH.MRD.CRC)

FRENCH.MRD.CRC PART I Inclusion criteria * Colon or rectal cancer, clinical tumor stage I-III. * Patient 18 years or older. * Scheduled for curative intent resection surgery (including "compromised" curative resections). Exclusion criteria * Hereditary colorectal cancer linked to familial colonic polyposis or Lynch syndrome. * Verified distant metastases. * Malignant colorectal polyps diagnosed after polypectomy. * Patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study. * Pregnant or nursing woman, or in childbearing age and not willing to use contraception * Protected and vulnerable adult * Not covered by Health insurance * Patient unable to understand and sign written informed consent. FRENCH.MRD.CRC PART II Inclusion criteria * Participation in FRENCH.MRD.CRC part 1 - SURGERY * Colorectal cancer, UICC stage III * Has received curative-intent resection and is a candidate for adjuvant chemotherapy (3- or 6-months regime) Exclusion criteria * Inflammatory bowel disease (Crohn's disease or ulcerative colitis) related colon cancer * Not treated with adjuvant chemotherapy despite indication (incomplete treatment not included) * Treated with neoadjuvant chemo-radiation therapy * Synchronous colorectal and non-colorectal cancer diagnosed per operative (except skin cancer other than melanoma) * Other cancers (excluding colorectal cancer or skin cancer other than melanoma) within 3 years from eligibility screening * Patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study