Vasodilator and Exercise Study for DMD (VASO-REx)
Recruiting
Phase 2
Interventional Study
Duchenne Muscular Dystrophy
Duchenne Disease
Muscular Dystrophy
Muscular Dystrophy in Children
Vasodilation
Exercise
DMD
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 6 and older
- Sex
- Male
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 50 (estimated)
- Sponsor
- University of Florida · Other
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About This Trial
Examining two strategies as potential adjuvant therapies for Duchenne muscular dystrophy (DMD); aerobic exercise training (to induce adaptations in skeletal muscle and improve cardiovascular health) and tadalafil, an FDA-approved vasodilator (to optimize blood flow and muscle perfusion which is impaired and often overlooked in DMD). Target: improved muscle function, vascular health, and DMD treatm…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Diagnosis of DMD confirmed by genetic report
* Minimum entry age of 6.0 years old
* Ambulatory
* On stable glucocorticoid regimen (for \> 3 months)
Exclusion Criteria:
* Contraindication to a Magnetic resonance Imaging examination (e.g. severe claustrophobia, magnetic implan…
Contacts