eGPA and Local Inflammation Within the Ear, Nose and Throat Area
Recruiting
Observational Study
EGPA - Eosinophilic Granulomatosis With Polyangiitis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 150 (estimated)
- Sponsor
- University Medical Center Groningen · Other
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About This Trial
Rationale: Eosinophilic Granulomatosis with Polyangiitis (eGPA), eosinophilic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) are airway diseases where eosinophils and interleukine-5 are involved in the pathogenesis. eGPA differs from the other diseases with respect to involvement of other organs. The investigators hypothesize that nasal microbiome dysbiosis with a central augmenting …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* 18 years of age
* able to give informed consent
* In CRSwNP group: availability of bilateral nasal polyps as diagnosed by endoscopy or CT scan
* In Severe asthma group: clinical diagnosis of asthma with forced expiratory volume at one second(FEV1) \<80% AND either FEV1 …
Contacts