Novel Approaches for Improving Vascular Function in Veterans With HFpEF
Recruiting
Phase 1
Interventional Study
Heart Failure With Preserved Ejection Fraction
Inflammation
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 90 (estimated)
- Sponsor
- VA Office of Research and Development · Federal
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About This Trial
This project will evaluate the impact of L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin administration on physical capacity and vascular function in Veterans with heart failure with preserved ejection fraction (HFpEF).
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 18 years or older and able to give written informed consent.
* New York Heart Association (NYHA) functional class I, II, or III.
* Left Ventricular Ejection Fraction (LVEF) \> 50%.
* Plasma Brain Natriuretic Peptide (BNP) equal to or greater than 150 pg/mL or NT-proBNP equ…
Contacts