Social Interaction Effects on Subjective Cognitive Decline
The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
Recruiting
Observational Study
Social IsolationSCDSubjective Cognitive DeclineMCIMild Cognitive ImpairmentADAlzheimer Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
45 – 85
Sex
Any
Study type
Observational
Participants needed
209 (estimated)
Sponsor
The First Affiliated Hospital with Nanjing Medical University · Other
Who this trial is looking for
This trial is looking for people who feel they are experiencing memory problems but do not have a diagnosis of mild cognitive impairment. Participants will help researchers understand how social interactions may affect brain function and the progression of memory decline.
Are You a Good Fit for This Trial?
You may be able to join if
I feel I have had continuous memory decline.
I do not have a diagnosis of mild cognitive impairment.
I can sign the consent form myself.
You may not be able to join if
I am under 45 years old or over 85 years old.
I have a history of vascular dementia or other brain diseases.
I cannot complete cognitive tests due to serious impairments.
I have abused drugs or alcohol in the last 6 months.
I am currently participating in other cognitive studies.
I have severe health issues like diabetes or heart disease.
I have claustrophobia or certain implants that prevent imaging.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The goal of this clinical trial is to learn about the effects of social isolation and social interaction on the risk of dementia progression and brain function in SCD
1. To explore the association between social isolation and lonely SCD populations and the occurrence and progression of MCI and AD through cross-sectional studies, cohort studies and randomized controlled trials of SCD;
2. To clarif…
The goal of this clinical trial is to learn about the effects of social isolation and social interaction on the risk of dementia progression and brain function in SCD
1. To explore the association between social isolation and lonely SCD populations and the occurrence and progression of MCI and AD through cross-sectional studies, cohort studies and randomized controlled trials of SCD;
2. To clarify the correlation between different carrier states, resting brain function connectivity characteristics, and dual-task walking ability of APOEε4 allele and the progression of SCD to MCI and AD during the cognitive progress of people with SCD affected by social isolation;
3. Establish a predictive model of cognitive decline from SCD to MCI and AD, and apply it to the SCD population to carry out individualized interventions;
4. Confirm the protective effect of social interaction on cognitive level and brain function in SCD patients.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* SCD
1. Self-perceived continuous cognitive decline compared with the previous normal state, and is not related to acute events;
2. After adjustment for age, gender, and years of education, the standard cognitive test is normal, or the diagnostic criteria for MCI are not m…
Inclusion Criteria:
* SCD
1. Self-perceived continuous cognitive decline compared with the previous normal state, and is not related to acute events;
2. After adjustment for age, gender, and years of education, the standard cognitive test is normal, or the diagnostic criteria for MCI are not met;
3. Selected candidates can sign the informed consent form themselves.
Exclusion Criteria:
* (a) Aged under 45 years or older than 85 years; (b) Vascular dementia or other central nervous system diseases; (c) Hachinski Ischemic Scale score \> 4 points; (d); Unable to complete neuropsychological tests (e.g., blindness, deafness, severe language impairment); (e) Drug abuse or alcohol dependency within the last 6 months; (f) Current participation in other cognition studies; (g) Severe diabetes mellitus, or severe cardiovascular disease, cerebrovascular disease, liver diseases, kidney diseases, psychiatric disorders; (h) Contraindications to imaging techniques: claustrophobia, metallic implants (e.g., intracranial metal clips), electronic devices (e.g., cardiac pacemakers)
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