Exercise Program for Chronic Obstructive Pulmonary Disease
Tissue Regeneration in Patients With Chronic Obstructive Pulmonary Disease After an Exercise Intervention.
Recruiting
N/AInterventional Study
Chronic Obstructive Pulmonary Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
50 – 85
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
80 (estimated)
Sponsor
Uppsala University · Other
Who this trial is looking for
This trial is looking for people with Chronic Obstructive Pulmonary Disease (COPD) to take part in an exercise program. Participants will undergo assessments before and after the program to see how exercise might help improve lung function and quality of life.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Chronic Obstructive Pulmonary Disease.
My lung capacity is between 30% and 85% of what is normal.
I am following my doctor's treatment plan for COPD.
I have not smoked for at least one year.
I have not had any COPD flare-ups in the last 4 weeks.
My BMI is between 18 and 35.
I do not have other serious health problems affecting my ability to exercise.
You may not be able to join if
I regularly participate in special exercise sessions.
I have unstable heart or lung disease.
I currently smoke.
My doctor thinks I should not take part in an exercise program.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The main objective of this project is to identify mechanisms for lung regeneration in patients with COPD induced by exercise training. The hypothesis is that adjusted exercise training improves disease outcome in these patients by decrease remodelling processes linked to oxidative stress, inflammatory and/or immunological pathways in the lung. Along the way, the investigator also expect to identif…
The main objective of this project is to identify mechanisms for lung regeneration in patients with COPD induced by exercise training. The hypothesis is that adjusted exercise training improves disease outcome in these patients by decrease remodelling processes linked to oxidative stress, inflammatory and/or immunological pathways in the lung. Along the way, the investigator also expect to identify (or validate) biomarkers mirroring systemic processes such as reduced inflammation and ameliorating the epithelial barrier in these patients. These events may additionally act as potential targets for interventions.
Objectives (i) Evaluate biomarkers for regenerative processes, matrix turnover, stem cell activity and inflammatory patterns in lung tissue biopsies, blood- and urine samples correlated to vital lung parameters and physical capacity, before and after attending an exercise-training program.
(ii) Study the effects of exercise training on the pulmonary ventilation/perfusion ratio and quality of life.
(iii) Evaluate the relation between pathophysiology in the lung evaluated by CT scan, and systemic response measured by muscle biopsies and biomarkers in blood/urine.
(iv) Investigate in vitro cell behaviour and remodelling/regenerative processes altered in COPD patients upon exercise training (aim 1).
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Forced expiratory volume in one second (FEV1) 85-30 % of predicted post bronchodilator
* Optimal medical treatment according to GOLD and the Swedish National Guidelines
* Absence of other significant diseases that could contribute to physical exercise limitation
* Non-smoking …
Inclusion Criteria:
* Forced expiratory volume in one second (FEV1) 85-30 % of predicted post bronchodilator
* Optimal medical treatment according to GOLD and the Swedish National Guidelines
* Absence of other significant diseases that could contribute to physical exercise limitation
* Non-smoking since at least one year
* Free from exacerbations (last 4 weeks)
* BMI = 18- 35
Exclusion Criteria:
* Regular participation in adjusted/specially designed exercise sessions
* Unstable cardiovascular or pulmonary disease
* Smoking
* Any other criteria that at the discretion of the investigator prevent the study subject from participating in an exercise-training program
Contacts
No contact information available.
What are you hoping to find?
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.