No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 – 80
Sex
Any
Study type
Observational
Participants needed
100 (estimated)
Sponsor
Anhui Medical University · Other
Who this trial is looking for
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The purpose of this study is to explore the mechanism of cognitive impairment in patients with symptomatic intracranial atherosclerotic stenosis (ICAS), and further plans to explore the impact of different treatment options on cognitive function in symptomatic ICAS patients.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age between 18 and 80 years
* Severe stenosis (≥70%-99%) of atherosclerotic internal carotid artery (C6 segment, C7 segment) or middle cerebral artery (M1 segment) confirmed by digital subtraction angiography (DSA) or at least two of the following non-invasive examinations: ma…
Inclusion Criteria:
* Age between 18 and 80 years
* Severe stenosis (≥70%-99%) of atherosclerotic internal carotid artery (C6 segment, C7 segment) or middle cerebral artery (M1 segment) confirmed by digital subtraction angiography (DSA) or at least two of the following non-invasive examinations: magnetic resonance angiography (MRA), computed tomography angiography (CTA), or transcranial Doppler (TCD)
* Transient ischemic attack (TIA) or minor stroke (National Institute of Health Stroke Scale \[NIHSS\] score ≤ 4 points)
* Right-handed and able to cooperate in neuropsychological tests
* At least 14 days post-onset of cerebral infarction or TIA
* Signed informed consent
Exclusion Criteria:
* Other diseases that affect cognitive function, such as cerebral hemorrhage, •Parkinson's disease, neurosyphilis, dementia, tumors, etc.
* Right upper limb hemiplegia, aphasia, visual field defects, or visual impairments
* More than 50% stenosis of the extracranial internal carotid artery, the vertebral artery, or the basilar artery
* Vasculitis, moyamoya disease, and cardiogenic stroke
* Previous history of head and neck stent implantation, carotid endarterectomy, aneurysm embolization, or other intracranial surgeries
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