Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks
Recruiting
N/A
Interventional Study
Beckwith-Wiedemann Syndrome
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Female
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 208 (estimated)
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Other
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About This Trial
Pathogenic variants in subcortical maternal complex (SCMC) have been identified not only in mothers of Beckwith-Wiedemann syndrome (BWS) babies but also in women with reproductive disturbances such as failed pregnancy attempts and recurrent pregnancy loss. Based on the higher incidence of BWS in children born from Assisted Reproductive Technology (ART), this project aims to investigate incidence a…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Cohort 1: healthy women with offspring affected by BWS and peculiar reproductive history from our population of clinically and molecularly diagnosed BWS families;
* Cohort 2: women under 35 undergoing ART for infertility (defined as failure to achieve a pregnancy after 12 mont…
Contacts