Sleep, Memory, and Brain Development in Young Children
Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition
Recruiting
N/AInterventional Study
Memory
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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At a Glance
Age
36 Months – 60 Months
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
180 (estimated)
Sponsor
University of Maryland, College Park · Other
Who this trial is looking for
This trial is looking for children aged 3 to 5 years who regularly take naps. Participants will help researchers understand how sleep affects memory and brain development over time by undergoing assessments every six months.
Are You a Good Fit for This Trial?
You may be able to join if
I am 36 to 60 months old.
I take naps 5 or more days a week.
I sleep independently without sharing a bed.
You may not be able to join if
I have a diagnosed sleep disorder (other than mild parasomnia).
I currently take medications that affect sleep or mood.
I traveled beyond 1 time zone in the past month.
I have a fever or symptoms of respiratory illness right now.
I have a physical handicap that affects testing.
I have a diagnosed developmental disability.
I have a history of neurological injury.
I have metal in my body that prevents an MRI.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
To examine the relations between sleep (nap transitions, sleep physiology), memory, and brain development longitudinally, the researchers will assess n=180 children (in order to acquire n=152 usable data sets) who are 36-54 months of age and habitual nappers at enrollment. In each wave, the researchers will assess memory, memory change over a nap and equivalent waking interval, sleep physiology of…
To examine the relations between sleep (nap transitions, sleep physiology), memory, and brain development longitudinally, the researchers will assess n=180 children (in order to acquire n=152 usable data sets) who are 36-54 months of age and habitual nappers at enrollment. In each wave, the researchers will assess memory, memory change over a nap and equivalent waking interval, sleep physiology of the nap, and brain structure and function (using Magnetic Resonance Imagining or MRI). Additionally, overnight sleep physiology will be assessed in all participants. Waves will take place approximately every 6 months. For all children, three waves will be collected. With these data, the researchers will address the following aims:
* Examine neural markers that predict the sleep transition (Aim 1);
* Examine changes in sleep-dependent memory processing (mnemonic discrimination) over both nap and overnight sleep intervals, across the sleep transition (Aim 2);
* Examine changes in sleep microstructure in both nap and overnight sleep across the sleep transition (Aim 3)
* Examine interrelations among brain, memory and sleep microstructure across the sleep transition (Aim 4)
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. 36-60 months at the time of enrollment
2. must be a habitual napper (defined as napping 5 or more days/week on average for the past month)
3. must sleep independently (not bedsharing; in order to maintain consistent sleep not interrupted by others)
Exclusion Criteria:
1. di…
Inclusion Criteria:
1. 36-60 months at the time of enrollment
2. must be a habitual napper (defined as napping 5 or more days/week on average for the past month)
3. must sleep independently (not bedsharing; in order to maintain consistent sleep not interrupted by others)
Exclusion Criteria:
1. diagnosis of any sleep disorder (other than mild parasomnia which is routine at this age) past or present (Child's Sleep Habit Questionnaire)
2. current use of psychotropic or sleep-altering medications (Developmental, Health, and Environment Questionnaire)
3. traveling beyond 1 time zone within 1 month prior to testing (phone screening)
4. fever or symptoms of respiratory illness at the time of testing (phone screening)
5. physical handicap which interferes with assessments (vision, hearing impairment; phone screening)
6. diagnosed developmental disability (Developmental, Health, and Environment Questionnaire)
7. history of neurological injury such as history of seizures, brain tumor, or stroke (phone screening)
8. presence of metal in the body (e.g., implant of any form) or other contraindication for MRI (e.g., claustrophobia, which is rare at this age).
9. external influences on nap habits (e.g., inability to nap due to school or caregiver schedule or interfering activities during a typical naptime) including if the child will enroll in full-day kindergarten by the end of the study. Caregivers will also be queried for the presence of interfering activities throughout enrollment (e.g., ecological momentary assessment (or EMA), sleep diaries at each wave).
Contacts
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