Adding Urea to the Final Dialysis Fluid
Recruiting
Phase 1
Phase 2
Interventional Study
Dysequilibrium Syndrome
ESRD
Hyperkalemia
Metabolic Acidosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 20 (estimated)
- Sponsor
- University of California, San Francisco · Other
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About This Trial
At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations. These patients cannot be dialyzed aggressively as the lowering of serum BUN may results in disequilibrium syndrome but on the other hand they need aggressive dialysis in order to lower their serum potassium or fix their severe acidosis. If one is …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Serum Urea \> 120
* Serum Potassium \> 5.5 or serum CO2 \< 15 or need for aggressive dialysis due to toxic ingestion
* need for dialysis
Exclusion Criteria:
* Pediatric
* need for CRRT
Contacts