This study is looking at two new parameters, aSID and ChU, to see if these can help physicians to distinguish between different causes of low sodium levels (hyponatremia) in Patients taking a medicament against high blood pressure (thiazide). Researchers also want to see if using these new parameters to decide on treatment works just as well, or better, than the current standard treatments.
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Eligibility Criteria
Inclusion Criteria:
* Hospitalized patients presenting at University Hospital Basel
* aged 18 years or older
* able to give informed consent as documented by signature
* with serum sodium level \< 133 mmol/l and serum osmolality \< 300 mOsm/kg
* with treatment with thiazide or thiazide-like diureti…
Inclusion Criteria:
* Hospitalized patients presenting at University Hospital Basel
* aged 18 years or older
* able to give informed consent as documented by signature
* with serum sodium level \< 133 mmol/l and serum osmolality \< 300 mOsm/kg
* with treatment with thiazide or thiazide-like diuretic
Exclusion Criteria:
* symptomatic hyponatremia in need of 3% hypertonic solution or intensive care treatment
* inability or contraindications to undergo the trial (i.e., any acute severe cardiovascular event requiring an immediate intervention)
* decompensated liver cirrhosis CHILD C
* decompensated heart failure NYHA III or higher
* severe valve impairment
* untreated adrenal insufficiency
* severe kidney disease in need of dialysis
* pregnancy or breastfeeding
* end of life care
* inability to follow the study procedures (i.e., language problem, dementia or critical illness).
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