Promoting Diagnosis and Management of AL in Italy (ProDigALIty)

Recruiting Observational Study
AL Amyloidosis Smoldering Multiple Myeloma Monoclonal Gammopathy of Undetermined Significance
No Placebo Group Every participant receives an active treatment — no one gets a placebo. No Study Drug Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 – 99
Sex
Any
Study type
Observational
Participants needed
760 (estimated)
Sponsor
Fondazione IRCCS Policlinico San Matteo di Pavia · Other
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About This Trial
The investigators plan to establish a dedicated network of Italian Hematologic Departments interconnected with the Amyloidosis Research and Treatment Center in Pavia to: 1. Implement a biomarker-based screening strategy to promote early diagnosis of AL amyloidosis among at-risk patients, including patients with monoclonal gammopathy of undetermined significance, MGUS, and altered free light chain…
Trial Locations
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Eligibility Criteria
PART A Inclusion Criteria: * diagnosis of MGUS with altered FLCR or SMM; * treatment-naïve; * age ≥18 years; * ability to understand and willingness to sign an informed consent; * planned follow-up at participating center. Exclusion Criteria: * Diagnosis of symptomatic monoclonal gammopathies; *…
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