Real-world Registry for Pulmonary Hypertension and ILD
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Recruiting
Observational Study
Pulmonary Hypertension Due to Lung Diseases and HypoxiaPulmonary HypertensionInterstitial Lung Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
900 (estimated)
Sponsor
United Therapeutics · Industry
Who this trial is looking for
This trial is looking for adults with pulmonary hypertension related to interstitial lung disease. Participants will share information about their health and treatments to help improve understanding of these conditions.
Are You a Good Fit for This Trial?
Must not be takingInhaled treprostinil
You may be able to join if
I am 18 years old or older
I have been diagnosed with fibrotic interstitial lung disease
I have confirmed pulmonary hypertension as tested by doctors
I am not receiving inhaled treprostinil at the start of the trial
I am willing to provide informed consent
I can complete surveys in English or Spanish
You may not be able to join if
I have a confirmed diagnosis of Group 1, 2, 4, or 5 pulmonary hypertension
I have a confirmed diagnosis of Group 3 pulmonary hypertension related to lung diseases other than fibrotic interstitial lung disease
I am receiving inhaled treprostinil at the start of the trial
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This is a prospective, real world, multicenter, registry of patients with pulmonary hypertension associated with interstitial lung disease (PH-ILD) and interstitial lung disease (ILD).
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
1. Adults aged 18 years or older
2. Diagnosis of fibrotic ILD based on high-resolution computed tomography imaging, including but not limited to:
1. Idiopathic interstitial pneumonia, including idiopathic pulmonary fibrosis
2. Autoimmune ILD
3. Chronic hypersensitivity…
Inclusion Criteria:
1. Adults aged 18 years or older
2. Diagnosis of fibrotic ILD based on high-resolution computed tomography imaging, including but not limited to:
1. Idiopathic interstitial pneumonia, including idiopathic pulmonary fibrosis
2. Autoimmune ILD
3. Chronic hypersensitivity pneumonitis
4. Nonspecific interstitial pneumonia
5. Occupational lung disease
6. Combined pulmonary fibrosis and emphysema with fibrosis greater than the extent of emphysema on lung imaging as determined by the Investigator
3. For patients to be eligible for Cohorts 1 to 3: RHC confirmed PH (mean pulmonary artery pressure \>20 mmHg, pulmonary artery wedge pressure
≤15 mmHg, pulmonary vascular resistance \>2 WU).
4. For patients to be eligible for Cohort 1, they must not be receiving inhaled treprostinil at Baseline.
5. For patients to be eligible for Cohort 2, they must have initiated
Tyvaso/Tyvaso DPI at 1 of the following time points:
1. Baseline
2. ≤90 days prior to Baseline 6. For patients to be eligible for Cohort 3, they must be receiving Tyvaso/Tyvaso DPI at Baseline and for \>90 days prior to Baseline. 7. For patients to be eligible for Cohort 4: Prior RHC not meeting the definition of PH as described in Inclusion Criterion 3 but has a pulmonary artery wedge pressure ≤15 mmHg. 8. Co-enrollment in other observational or interventional studies is permitted. 9. Patient is willing and able to provide informed consent and complete surveys/questionnaires in English or Spanish.
Exclusion Criteria:
1. Confirmed diagnosis of Group 1, 2, 4, or 5 PH
a. In cases in which a patient has a diagnosis of PH-ILD along with a concomitant diagnosis of another PH group (eg, Group 1), enrollment may be permitted at the Investigator's discretion if, in their clinical judgment, PH-ILD is the predominant driver of the patient's PH.
2. Confirmed diagnosis of Group 3 PH associated with lung diseases and or hypoxia other than fibrotic ILD, as outlined in Inclusion Criterion 2.
3. Patients receiving inhaled treprostinil (Yutrepia™) at Baseline. Patients receiving other forms of PH therapy will be eligible for enrollment.
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.