Neuromodulation Effect of Focused Ultrasound for Motor Recovery in Patients With Stroke

Inclusion Criteria: * Patients with stroke (including hemorrhagic or ischemic stroke) diagnosed by a board-certificated physician. * Occurrence of stroke within three months. * Upper limb muscle strength ≤ 4 points according to the Medical Research Council Manual Muscle Testing scale. * No previous history of stroke, epilepsy, dementia, Parkinson's disease, or other neurodegenerative diseases. * Patients could maintain sitting posture for more than 15 minutes on a chair. * 18 years of age or older. Exclusion Criteria: * History of recurrent stroke, traumatic brain injuries, brain tumors, spinal cord injury, Parkinson's disease or other musculoskeletal system diseases that may affect evaluation and treatment. * Contraindications to focused ultrasound, including pregnancy, cardiac pacemaker or implantable medical device, abnormal connective tissue diseases, coagulopathy (PLT\<100,000/μL, PT\>14 seconds, APTT\>36 seconds, INR\>1.3), implants near or in the brain, or those deemed Unsuitable for this treatment by the physician. * Unable to cooperate with treatment or functional assessment due to impaired consciousness or aphasia; inability to informed consent. * Patient with cranial bone factor causing the inability of tFUS penetration. * Patient under anticoagulants with coagulopathy (PLT\<100,000/μL, PT\>14 seconds, APTT\>36 seconds, INR\>1.3) * Patients who are not suitable for undergoing CT imaging examination; * Major physical illnesses and neurological disorders (such as epilepsy, brain surgery, etc.) * Patients with metallic implants in their bodies; * Patients taking tricyclic antidepressants, analgesics, or using antiepileptic drugs * Individuals experiencing sleep disorders during tFUS treatment; * Individuals with history of alcoholism * Patients with severe or uncontrollable intracranial pressure; * Patients requiring anticoagulants; * Any intracranial space-occupying lesions; * Significant calcification of intracranial vessels based on pre-treatment CT imaging; * Subjects with lesions/wounds on the scalp in the target region.