This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation
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Eligibility Criteria
Inclusion Criteria:
* Patients with Acute respiratory failure needing mechanical ventilation
* Diagnosis of Severe ARDS with severity: PF ratio \< 150, with PEEP/CPAP \> 5
Exclusion Criteria:
* r2 \< 0.95, monitored on the ventilator
* Expiratory flow that is not first-order or non-exponential de…
Inclusion Criteria:
* Patients with Acute respiratory failure needing mechanical ventilation
* Diagnosis of Severe ARDS with severity: PF ratio \< 150, with PEEP/CPAP \> 5
Exclusion Criteria:
* r2 \< 0.95, monitored on the ventilator
* Expiratory flow that is not first-order or non-exponential decay
* Patients with Nor-epinephrine requirements \> 0.1 mcg/kg/min within 2 hours of intubation
* Patients requiring ECMO ( Extracorporeal membrane oxygenation)
* Patients with COPD or pulmonary fibrosis with a premorbid FEV1 \< 1.5 L
* Severe atherosclerotic vascular disease
* Patients with a chest tube, intra-abdominal hypertension or with its risk factors
* Patients with structural heart disease including pulmonary hypertension (RVSP \> 45) and heart failure
* All comfort care orders in the ICU
* Patients who underwent tracheostomy
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