Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers
Recruiting
Observational Study
SDH-Related Familial Paraganglioma
SDHx-Related Syndromes
SDH Gene Mutation
Environmental Exposure
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 1,300 (estimated)
- Sponsor
- Assistance Publique - Hôpitaux de Paris · Other
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About This Trial
The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and/or domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with para…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor
* Controls: SDHx mutation carriers with no SDHx-related tumor
Exclusion Criteria:
* Incapacity to exercise free and informed consent for the study
* Patient under tutorship or guardianship or legal safeguard
Contacts