Modeling Ocular Developmental Diseases From 3D Cultures of Optic Vesicle Organoids Derived From hiPSCs of Patients With Ocular Malformations
Recruiting
Observational Study
Eye Abnormalities
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 6 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 20 (estimated)
- Sponsor
- University Hospital, Toulouse · Other
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About This Trial
Ocular morphogenesis is a complex process starting as early as the 4th week of embryonic life, involving interactions between varioustissues of different origin and conserved genes. Anomalies in ocular development , often of genetic origin, pose diagnostic and therapeutic challenges. Animal models are limited, so human-induced pluripotent stem cell (hiPSC)-derived optic vesicle containing brain or…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Affiliated with a social security scheme.
* Patients with ocular malformations.
* Signed informed consent obtained from the patient and/or their legal representatives.
Exclusion Criteria:
* Inability to understand the nature and objectives of the study and/or difficulties in…
Contacts