No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
60 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
100 (estimated)
Sponsor
University of Washington · Other
Who this trial is looking for
This trial is looking for older adults who have spent time in an ICU and are recovering from critical illness. Participants will take part in activities to improve their thinking skills and sleep.
Are You a Good Fit for This Trial?
You may be able to join if
I am 60 years old or older.
I am currently hospitalized at University of Washington Medical Center or Harborview Medical Center.
I stayed in the ICU for more than 24 hours.
I am recovering from critical care and have been moved to acute care or discharged from the ICU.
I speak fluent English or Spanish.
I was independent in daily activities before my hospitalization.
You may not be able to join if
I have a history or suspicion of Alzheimer's disease or dementia.
I am currently taking anti-dementia medication.
I have a history of bipolar disorder or schizophrenia.
I have had an acute stroke or traumatic brain injury.
I have severe vision impairment.
I have severe hearing impairment.
I have severe paralysis or dominant arm paresis.
I was transferred from a skilled nursing care facility or an inpatient rehabilitation facility.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which contribute to higher risk for cognitive decline related to Alzheimer's disease and related dementias. Sl…
Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which contribute to higher risk for cognitive decline related to Alzheimer's disease and related dementias. Sleep and activity are essential for recovery from critical illness, yet ICU survivors experience both sleep deficiency and profound inactivity. About 75-80% of ICU patients experience circadian dysrhythmia, which contributes to cognitive decline and increases likelihood of developing Alzheimer's disease and related dementias. The scientific premises of the proposed study are: 1) a combined sleep promotion and cognitive training intervention will have synergistic effects to mitigate the risk of cognitive impairment and development of Alzheimer's disease and related dementias in older ICU survivors; and 2) chronotherapeutic timing of interventions (i.e., adjusting timing of interventions according to circadian rhythm) may improve intervention efficacy.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Age greater than or equal to 60 years old
* Current hospitalization at University of Washington Medical Center or Harborview Medical Center
* Intensive care unit (ICU) length of stay greater than 24 hours
* Recovery from critical care status to acute care status, and/or discha…
Inclusion Criteria:
* Age greater than or equal to 60 years old
* Current hospitalization at University of Washington Medical Center or Harborview Medical Center
* Intensive care unit (ICU) length of stay greater than 24 hours
* Recovery from critical care status to acute care status, and/or discharge out of ICU
* Fluent in English or Spanish
* Functional independence on activities of daily living prior to hospitalization (Katz Index = 6)
Exclusion Criteria:
* Documented history or suspicion of Alzheimer's disease or dementia, or current prescription of anti-dementia medication
* Documented history of bipolar disorder or schizophrenia
* Documented acute stroke or traumatic brain injury
* Severe vision impairment
* Severe hearing impairment
* Severe paralysis or dominant arm paresis
* Transfer from skilled nursing care facility or inpatient rehabilitation facility
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