Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
40 – 75
Sex
Any
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
30 (estimated)
Sponsor
University of Florida · Other
Who this trial is looking for
This trial is looking for people with knee osteoarthritis who have moderate to severe knee pain. Participants will use cannabidiol (CBD) to see if it helps relieve their pain during physical activities.
Are You a Good Fit for This Trial?
Rules you outSeizure disorderTraumatic brain injuryLiver diseaseKidney diseaseCardiovascular diseases
You may be able to join if
I have been diagnosed with knee osteoarthritis.
I have moderate to severe knee pain of 4 or more out of 10.
You may not be able to join if
I am pregnant or breastfeeding.
I currently use cannabis products.
I have a medical condition that could affect my safety.
I have had major surgery in the last 3 months.
I have used another investigational drug in the last 3 months.
My BMI is 45 or higher.
I take certain enzyme-modifying medications.
I have a history of suicidal thoughts or behavior.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population. Many physically active Americans have reported pain-relieving effects of cannabidiol (CBD) that can reduce or eliminate use of nonsteroidal anti-inflammatory drugs (NSAIDs) for activity-related pain with minimal to no side effects. Long-t…
Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population. Many physically active Americans have reported pain-relieving effects of cannabidiol (CBD) that can reduce or eliminate use of nonsteroidal anti-inflammatory drugs (NSAIDs) for activity-related pain with minimal to no side effects. Long-term use of over-the-counter medications, including NSAIDs, can pose a significant health risk, and therefore clinical research on the safety and efficacy of CBD is needed.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
1. established clinical diagnosis of knee osteoarthritis (KOA)
2. moderate to severe knee pain (≥4/10) with physical activity in one or both knees
Exclusion Criteria:
1. pregnant (urine pregnancy test) or lactating
2. current cannabis (THC and/or CBD) use (urine drug screen)
3…
Inclusion Criteria:
1. established clinical diagnosis of knee osteoarthritis (KOA)
2. moderate to severe knee pain (≥4/10) with physical activity in one or both knees
Exclusion Criteria:
1. pregnant (urine pregnancy test) or lactating
2. current cannabis (THC and/or CBD) use (urine drug screen)
3. any prior or ongoing medical condition that, in the investigators' opinion, could adversely affect the safety of the subject
4. any major surgery within 3 months prior to recruitment or planned orthopedic surgery for any time during this study which would interfere with the ability to report pain or quality of life outcome measures
5. any exposure to another investigational drug within 3 months prior to screening
6. BMI ≥ 45
7. current use of any enzyme-modifying drugs, including strong inhibitors or strong inducers of cytochrome P (CYP) enzymes
8. history of:
1. suicidal ideation or self-harm behavior
2. seizure disorder or traumatic brain injury,
3. liver or kidney disease, and
4. cardiovascular diseases
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.