A Study of HS-20117 Combined With Aumolertinib in Participants With Advanced Non-Squamous Non-Small Cell Lung Cancer

Inclusion Criteria: * Males or females aged 18 - 75 years (inclusive). * Participants with newly diagnosed histologically or cytologically confirmed, locally advanced or metastatic EGFR-sensitive mutated NSCLC (stage IIIB/IIIC/IV) that is treatment naive and not amenable to curative therapy including surgical resection or chemoradiation. * Agree to provide fresh or archival tumor tissue. * At least one target lesion per the RECIST v1.1. * ECOG performance status of 0-1. * Minimum life expectancy \> 12 weeks. * Males or Females should be using adequate contraceptive measures throughout the study. * Females must not be pregnant at screening or have evidence of non-childbearing potential. * Have signed Informed Consent Form. Exclusion Criteria: * Received or are receiving the following treatments: 1. Previous or current treatment with MET targeted therapy or EGFR targeted antibodies or antibody-drug conjugates (ADC). 2. Traditional Chinese medicine indicated for tumors, major surgery or other local therapy within washout period to the first dose of study drug. 3. Presence of pleural effusion/ascites requiring clinical intervention; presence of pericardial effusion. 4. Other investigational non-anti-tumor drugs, strong CYP3A4 inhibitors, strong inducers, drugs that are sensitive substrates of BCRP or P-gp, or drugs that prolong the QT interval within the washout period. * Presence of Grade ≥ 2 toxicities due to prior anti-tumor therapy. * History of other primary malignancies. * Untreated, or active central nervous system metastases. * Inadequate bone marrow reserve or organ functions. * Severe, uncontrolled or active cardiovascular disorders. * Severe or uncontrolled systemic diseases. * Severe bleeding symptoms or bleeding tendencies. * Severe arteriovenous thrombosis occurred. * Serious or active infection. * Active infectious diseases. * Interstitial lung disease (ILD). * Serious neurological or mental disorders. * History of hypersensitivity to any component of HS-20117 and Aumolertinib or their similar drugs. * Female subjects who are pregnant, lactating, or planning to become pregnant or breastfeed during the study period or within 6 months after the last dose of the study drug. * Subjects with a history of severe allergic reactions or those who have experienced severe infusion reactions * Participants with any condition that compromises the safety of the participant or interferes with the assessment of the study, as judged by the investigator.