Cognitive Behavioral Therapy for Insomnia in MS

Efficacy of Cognitive Behavioral Therapy for Insomnia to Treat Insomnia Symptoms in Individuals With Multiple Sclerosis

Recruiting Phase 2 Interventional Study
Multiple Sclerosis Insomnia
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 65
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
70 (estimated)
Sponsor
University of Kansas Medical Center · Other
Who this trial is looking for

This trial is looking for adults with multiple sclerosis who struggle with insomnia. Participants will receive cognitive behavioral therapy to help improve their sleep symptoms and overall quality of life.

Are You a Good Fit for This Trial?
Must not be taking BenzodiazepinesNon-benzodiazepinesMelatonin
Rules you out Sleep apneaRestless legs syndromeSevere mental illnessStrokeParkinson's disease

You may be able to join if

  • I am between 18 and 65 years old.
  • I have been diagnosed with relapsing-remitting or secondary progressive MS.
  • I have mild-to-moderately severe disability.
  • I have trouble sleeping at least 3 nights a week for the past 3 months.
  • I score 10 or more on the Insomnia Severity Index.
  • I speak English.
  • I have access to the internet and a computer, tablet, or smartphone.
  • I have at least a high school diploma or equivalent.

You may not be able to join if

  • I have a known untreated sleep disorder.
  • I score more than 3 on the STOP BANG test.
  • I am currently taking medications for sleep like benzodiazepines or melatonin.
  • I have severe depression or suicidal thoughts.
  • I have severe anxiety.
  • I have a history of substance abuse in the last 2 years.
  • I am currently pregnant or planning to become pregnant soon.
  • I have had a relapse or used corticosteroids in the past 8 weeks.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
The incidence of insomnia is estimated to be as high as 90% in individuals with MS due to insomnia being underdiagnosed. Sleep disturbances in people with MS have been associated with reduced cognitive performance, physical function, psychological well-being, quality of life, and occupational function, as well as increased prevalence of fatigue, pain, depression, and anxiety. The objective of the …
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * 18-65 years old * Diagnosis of relapsing-remitting or secondary progressive MS based on established guidelines20 and verified by their neurologist * Mild-to-moderately severe disability (≤ 6 on Patient Determined Disability Steps (PDDS) scale) * Report of difficulty falling as…
Contacts

Eryen Nelson, MPH

913-945-7349

enelson5@kumc.edu

CONTACT

Catherine Siengsukon, PhD

913-588-6913

csiengsukon@kumc.edu

CONTACT