Empagliflozin for Pediatric Chronic Kidney Disease
Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease
Recruiting
Early Phase 1
Interventional Study
Chronic Kidney Diseases
Pediatric Kidney Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 12 – 25
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 40 (estimated)
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago · Other
Who this trial is looking for
This trial is looking for youth with chronic kidney disease (CKD) to see if a treatment called empagliflozin can help improve kidney and heart health. Participants will either receive this medication or continue their usual care for three months.
Are You a Good Fit for This Trial?
You may be able to join if
- I have chronic kidney disease (Stage 3-4).
- My estimated kidney function is 20-60 mL/min/1.73m2.
You may not be able to join if
- I have heart disease.
- I have diabetes.
- I am pregnant.
- I have received a solid organ transplant.
- I have a history of chemotherapy or stem cell transplant.
- I have moderate to severe persistent asthma.
- I have liver disease.
- I have class 2 or greater obesity.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The goal of this study is to learn if a clinical trial of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is possible in youth with chronic kidney disease (CKD). The investigators also plan to explore whether treatment with SGLT2i (Empagliflozin) helps improve risk factors for worsening kidney and heart disease. The main questions are:
1. Is enrolling 40 youth with CKD into a clinical trial o…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Stage 3-4 CKD; estimated GFR using CKiD U25-creatinine equation 20-60mL/min/1.73m2
Exclusion Criteria:
* Heart Disease
* Diabetes
* Pregnancy
* Recipient of solid organ transplant
* history of chemotherapy or stem cell transplant
* moderate to severe persistent asthma
* live…
Contacts