No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
60 (estimated)
Sponsor
Washington University School of Medicine · Other
Who this trial is looking for
This trial is looking for adults, either healthy or with Alzheimer’s disease, to test the safety of a new imaging agent called 18F-Fluselenamyl. Participants will undergo PET scans as part of the study.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 years or older
I am healthy or have Alzheimer's disease
You may not be able to join if
I am allergic to 18F-Fluselenamyl or its ingredients
I am allergic to 11C-PIB or its ingredients
I cannot give written consent or do not have someone to help me with consent
I do not want to have PET scans or tracer injections
I do not want to have an MRI
I have a serious health issue that could make the study risky for me
I am currently pregnant or breastfeeding
I have participated in certain radioactive studies in the past year
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this research study is to determine the safety of a radiotracer 18F-Fluselenamyl using positron emission tomography (PET) imaging.
Trial Locations
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City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Male or Female, any race
* Age ≥ 18 years
* Healthy volunteers or volunteers with Alzheimer's disease
Exclusion Criteria:
* Has hypersensitivity to 18F-Fluselenamyl or any of its excipients ;
* Has hypersensitivity to 11C-PIB or any of its excipients ;
* Incapable of providi…
Inclusion Criteria:
* Male or Female, any race
* Age ≥ 18 years
* Healthy volunteers or volunteers with Alzheimer's disease
Exclusion Criteria:
* Has hypersensitivity to 18F-Fluselenamyl or any of its excipients ;
* Has hypersensitivity to 11C-PIB or any of its excipients ;
* Incapable of providing written informed consent or lacking a legally authorized representative (LAR) to provide informed consent ;
* Unwilling or unable to undergo PET scans tracer injections ;
* Unwilling or unable to undergo MRI (Aim 2 and Aim 3)
* Any condition that, in the Investigator's opinion, could increase the risk to the participant, limit the participant's ability to tolerate the research procedures, or interfere with the collection/analysis of the data (e.g., renal or liver failure, advanced cancer);
* Women who are currently pregnant or breast-feeding;
* Current or recent (within 12 months prior to screening) participation in research studies involving radioactive agents such that the total research-related radiation dose to the participant in any given year would exceed the limits set forth in the U.S. Code of Federal Regulations (CFR) Title 21 Section 361.1.
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