Ultrasound-Guided Curved Needle Thread Carpal Tunnel Release: Efficacy and Safety of a Single-Center, Single-Arm Clinical Trial

Inclusion Criteria: 1. Aged between 40 and 70 years; 2. Exhibiting symptoms consistent with carpal tunnel syndrome (e.g., finger numbness, tingling, weakness, or pain; symptoms aggravated by repetitive or sustained gripping; symptoms worsening at night) and signs (sensory impairment or weakness in the hand; positive Tinel's sign or Phalen's test for the median nerve); 3. Meeting the diagnostic criteria for typical or possible carpal tunnel syndrome based on the Katz hand diagram for carpal tunnel syndrome \[14\]; 4. Ultrasound indicating thickening of the transverse carpal ligament, compressing the median nerve; 5. Ineffective conservative treatment (e.g., immobilization, oral NSAIDs, local corticosteroid injections) for more than 3 months; 6. Signing the informed consent form. Exclusion Criteria: 1. Ultrasound examination reveals bifurcation of the median nerve or the presence of a persistent median artery at the carpal tunnel entrance, or compression at the carpal tunnel caused by cysts, tumors, or fracture fragments; 2. Systemic infection or local infection at the surgical site; 3. Severe coagulation disorders; 4. Previous carpal tunnel syndrome surgery on the affected side for this operation; 5. Patients with uncontrolled epilepsy, cervical radiculopathy, or diabetic peripheral neuropathy; 6. Allergy to local anesthetics; 7. Inability to complete the questionnaire due to language or cognitive impairments; 8. Patients with severe heart, lung, liver, or brain diseases; 9. Patients with mental illnesses; 10. Participation in other clinical trials within the last three months; 11. Pregnant or breastfeeding women.