A Study of Nemtabrutinib in Participants With Moderate Hepatic Impairment (MK-1026-015)

Recruiting Phase 1 Interventional Study
Hepatic Impairment (HI)
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Healthy Volunteers Welcome You do not need to have the condition being studied to take part.
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At a Glance
Age
18 – 75
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
32 (estimated)
Sponsor
Merck Sharp & Dohme LLC · Industry
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About This Trial

The purpose of this study is to compare the plasma pharmacokinetics (PK) of nemtabrutinib (MK-1026) following a single oral dose of nemtabrutinib in participants with moderate hepatic impairment to that of healthy matched control participants and to evaluate the safety and tolerability of nemtabrutinib.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Has a body mass index (BMI) between 18.0 and 40.0 kg/m2, inclusive. * Is assigned male or female sex at birth. Participants assigned female sex at birth must not be pregnant or breast feeding and must be of nonchild bearing potential. * Who agrees to use contraception. * Has p…
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