ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
Recruiting
Phase 1
Phase 2
Interventional Study
Opioid Withdrawal
Chronic Pain
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 240 (estimated)
- Sponsor
- Medical University of South Carolina · Other
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About This Trial
This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid withdrawal; (2) a brief Cognitive Behavioral Intervention for pain (CBI); and (3) "accelerated" rTMS over the left dorsolateral prefrontal cortex, by examining standardized rep…
Trial Locations
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Eligibility Criteria
Inclusion criteria:
Age \>/= 18 years
English-speaking
On LTOT, defined as taking daily prescription opioid therapy for 90 days or more
Past week average morphine equivalent dose (MED) \>/= 20mg
Willing and able to complete written informed consent
Willing and able to use a mobile/cell phone
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