Psilocybin Therapy for Depression in Parkinson's Disease

Psilocybin Therapy for Depression in Parkinson's Disease

Recruiting Phase 2 Interventional Study
Parkinson Disease Depression
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
40 – 80
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
Joshua Woolley, MD, PhD · Other
Who this trial is looking for

This trial is looking for people with Parkinson's Disease and depression. Participants will receive psilocybin therapy to see if it helps improve their symptoms.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am between 40 and 80 years old.
  • I can speak and write in English.
  • I have been diagnosed with Parkinson's disease.
  • I currently have depressive symptoms.
  • I can attend all in-person visits at UCSF and some virtual visits.
  • I have a primary care provider or mental health professional managing my care.

You may not be able to join if

  • I experience psychotic symptoms that affect my insight.
  • I have significant cognitive impairment.
  • I regularly take medications that may interact with psilocybin.
  • I have a health condition that makes this study unsafe or unfeasible.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

Check Your Eligibility
About This Trial

The purpose of this study is to understand whether people with Parkinson's Disease and depression have improvement in their symptoms after psilocybin therapy.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Age 40 to 80 * Comfortable speaking and writing in English * Have neurologist-diagnosed idiopathic Parkinson's disease (PD), Hoehn and Yahr stages 1 to 3 during an "on" phase (time when medication/DBS for parkinsonian motor feature, including bradykinesia and rigidity is in ef…
Contacts

Brigette Sosa

(415) 935-3489

pdp2@ucsf.edu

CONTACT

Ellen Bradley, MD

CONTACT