Optic Nerve Involvement in Clinically Isolated Syndrome
Predictive Value of the Optic Nerve Involvement in Clinically Isolated Syndrome
Recruiting
N/A
Interventional Study
Clinically Isolated Syndrome
Multiple Sclerosis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 55
- Sex
- Any
- Study type
- Interventional
- Purpose
- Diagnostic
- Participants needed
- 200 (estimated)
- Sponsor
- University Hospital, Lille · Other
Who this trial is looking for
This trial is looking for adults with clinically isolated syndrome to see how optic nerve involvement can help predict multiple sclerosis. Participants will undergo MRI tests and must agree to be part of the study by giving their written consent.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 55 years old
- I have been diagnosed with clinically isolated syndrome for 6 months or less
- I have two brain/spinal cord MRI findings that suggest multiple sclerosis
- I have oligoclonal bands in my spinal fluid
- I will give my written consent
You may not be able to join if
- I have diabetes mellitus
- I have glaucoma
- I have retinopathy
- I have ametropia greater than 6 diopters
- I have had multiple sclerosis relapses in the past
- I have extensive myelitis affecting more than 3 vertebral bodies
- I have had bilateral optic neuritis without MRI lesions suggestive of multiple sclerosis
- I cannot have an MRI or a gadolinium injection
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Optic neuritis (ON) represents around 30% of clinical presentation of clinically isolated syndrome (CIS). Asymptomatic optic nerve involvement is very frequent in all stage of multiple sclerosis (MS) disease including the CIS. However, optic nerve is still not part of MS diagnosis criteria. The main objective of our regional and multicenter study is to evaluate the prognostic value of optic nerve …
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
* Patients between 18 and 55 years old
* Occurrence of CIS ≤ 6 months
* With two T2 hypersignals on brain/spinal cord MRI suggestive of MS or with oligoclonal bands
* Giving their written informed consent
Exclusion Criteria:
* Pathological conditions that may skew the optic ne…
Contacts