Cerebellum-Prefrontal Paired-Pulse Stimulation for Methamphetamine Use Disorder
Recruiting
N/AInterventional Study
Methamphetamine Use Disorder
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
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At a Glance
Age
18 – 60
Sex
Male
Study type
Interventional
Purpose
Treatment
Participants needed
90 (estimated)
Sponsor
Shanghai Mental Health Center · Other
Who this trial is looking for
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To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired cerebellar-medial prefrontal cortex (mPFC) pulses on methamphetamine use disorder patients and to develop a novel physiotherapeutic intervention to optimise the treatment and management.
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Eligibility Criteria
Inclusion Criteria
Participants will be eligible for inclusion if they meet the following criteria:
1. Methamphetamine is the primary substance of use, and the participant meets the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for moderate or severe methamphetamine…
Inclusion Criteria
Participants will be eligible for inclusion if they meet the following criteria:
1. Methamphetamine is the primary substance of use, and the participant meets the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for moderate or severe methamphetamine use disorder;
2. aged 18 to 60 years;
3. normal or corrected-to-normal vision and hearing, and right-handedness;
4. primary school education or above, with the ability to understand the questionnaires and behavioral task instructions.
Exclusion Criteria
Participants will be excluded if they meet any of the following criteria:
1. presence of metal objects in the body, such as metal dentures, orthodontic braces, bone fixation plates, aneurysm clips, or other metallic implants;
2. severe physical illness or chronic disease, including heart disease, severe hypertension, stroke, epilepsy, or history of head trauma;
3. comorbid psychiatric disorders, such as bipolar disorder, schizophrenia, or severe depression;
4. previous participation in transcranial magnetic stimulation- or electroencephalography-related studies;
5. refusal to participate in the study, poor compliance, or any other contraindications to transcranial magnetic stimulation.
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