Research on Biomarkers for Giant Cell Arteritis and PMR
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
Recruiting
Observational Study
Giant Cell ArteritisPolymyalgia Rheumatica
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
100 (estimated)
Sponsor
University of Bonn · Other
Who this trial is looking for
This trial is looking for adults aged 18 and over who have been diagnosed with giant cell arteritis or polymyalgia rheumatica. Participants will help researchers understand these conditions better through various tests and assessments.
Are You a Good Fit for This Trial?
You may be able to join if
I am 18 years or older.
I have been diagnosed with giant cell arteritis or polymyalgia rheumatica.
My doctor has confirmed my diagnosis.
I was diagnosed recently, within the last three days.
I have had a disease flare within the last three days.
You may not be able to join if
I have severe renal insufficiency.
I have other medical conditions that require treatment with glucocorticoids.
I have been diagnosed with other inflammatory rheumatic diseases.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The GCAIO study is an innovative, multimodal research initiative designed to enhance the understanding, diagnosis, and management of giant cell arteritis (GCA) and frequently associated polymyalgia rheumatica (PMR). This longitudinal study aims to dissect the complex immunological landscape and systemic manifestations of these conditions through a combination of diagnostic imaging and detailed imm…
The GCAIO study is an innovative, multimodal research initiative designed to enhance the understanding, diagnosis, and management of giant cell arteritis (GCA) and frequently associated polymyalgia rheumatica (PMR). This longitudinal study aims to dissect the complex immunological landscape and systemic manifestations of these conditions through a combination of diagnostic imaging and detailed immunological profiling.
The study focuses on three primary objectives: (1) Identifying and analyzing cytokine profiles and immune cell phenotypes, employing techniques like flow cytometry, enzyme-linked immunosorbent assays (ELISA), and next-generation sequencing to predict disease activity and therapeutic responses. (2) Advancing diagnostic and monitoring capabilities through the application of novel and established imaging technologies, including MRI, optical coherence tomography angiography (OCTA), and ultrasound. These modalities aim to improve the detection of neuro-ophthalmological, cardiac, and aortic complications in GCA, potentially offering more precise monitoring and earlier diagnosis. (3) Enhancing the understanding of PMR within the context of GCA by exploring specific biomarkers and advanced imaging to refine diagnostic accuracy and treatment strategies, thus improving patient outcomes.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Informed Consent: Participants (\>18 years) must provide written informed consent to voluntarily participate in the study.
* Confirmed Diagnosis: Diagnosis of GCA or PMR confirmed by the treating physician and fulfilling expanded ACR-EULAR classification criteria. Patients mus…
Inclusion Criteria:
* Informed Consent: Participants (\>18 years) must provide written informed consent to voluntarily participate in the study.
* Confirmed Diagnosis: Diagnosis of GCA or PMR confirmed by the treating physician and fulfilling expanded ACR-EULAR classification criteria. Patients must have been either newly diagnosed within the last three days or have experienced a disease flare within the same timeframe.
Exclusion Criteria:
* Severe Renal Insufficiency: Chronic glomerular filtration rate (GFR) less than 30 mL/min.
* Other Medical Conditions Requiring Glucocorticoids: Presence of medical conditions other than GCA or PMR that necessitate continuous or intermittent treatment with oral or parenteral glucocorticoids.
* Other Inflammatory Rheumatic Diseases: Patients with other inflammatory rheumatic diseases.
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