Radiation and Hormone Therapy for High-Risk Prostate Cancer
Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H)
Recruiting
Phase 2Interventional Study
High Risk Prostate Carcinoma
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
20 and older
Sex
Male
Trial phase
Phase 2
Study type
Interventional
Purpose
Treatment
Participants needed
33 (estimated)
Sponsor
Samsung Medical Center · Other
Who this trial is looking for
This trial is looking for men with high-risk prostate cancer. Participants will receive radiation therapy and hormone therapy after a specific procedure.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with prostate cancer in the last 6 months
I have high-risk prostate cancer
I am currently receiving hormone therapy or will receive it
I am over 20 years old
I have a good overall health status
I consented to the SpaceOAR procedure and this study
You may not be able to join if
I have had my prostate removed
I have had lower pelvic surgery including rectal cancer surgery
I have previous pelvic radiation therapy
I have lymph node metastasis or distant metastasis
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Dose increase after injection of biodegradable material A safety study of high-risk prostate cancer patients who underwent low-fractionation curative radiation therapy and hormone therapy
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
1. Histopathologically confirmed prostate adenocarcinoma within 6 months of study enrollment
2. Patients with prostate cancer at high risk or above (c T3a-T4 or grade group 4-5 or PSA \> 20 n g/mL) )
3. Patients who have undergone or are scheduled to undergo hormone therapy for …
Inclusion Criteria:
1. Histopathologically confirmed prostate adenocarcinoma within 6 months of study enrollment
2. Patients with prostate cancer at high risk or above (c T3a-T4 or grade group 4-5 or PSA \> 20 n g/mL) )
3. Patients who have undergone or are scheduled to undergo hormone therapy for high-risk prostate cancer
4. Adults over 20 years of age
5. Whole body performance ECOG 0-1
6. SpaceOAR Patients who consented to the procedure and study
Exclusion Criteria:
1. prostate removal surgery, Patients with a history of lower pelvic surgery including rectal cancer surgery
2. primary cancer Patients with posterior extracapsular extension
3. Medically biodegradable substances such as bleeding predisposition Patients for whom infusion is not appropriate
4. Patients with a history of previous pelvic radiation therapy
5. Patients with lymph node metastasis or distant metastasis
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