No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
45 – 80
Sex
Any
Study type
Observational
Participants needed
160 (estimated)
Sponsor
University of Minnesota · Other
Who this trial is looking for
This trial is looking for individuals with Parkinson's disease and healthy older and young adults. Participants will undergo a brain stimulation technique to help researchers study balance and walking in people with Parkinson's.
Are You a Good Fit for This Trial?
Rules you outDementiaMultiple sclerosis
You may be able to join if
I have been diagnosed with Parkinson's disease.
I am between 45 and 80 years old.
I can walk independently for 50 meters.
I am a healthy adult between 45 and 80 years old.
I am a healthy adult between 21 and 44 years old.
You may not be able to join if
I have fainting spells related to blood or stress.
I take blood-thinning medication.
I have a condition affecting my ability to stand.
I have a history of seizures or stroke.
I have any metal implants in my head.
I have a pacemaker or any other implanted device.
I have had surgery on my brain or heart.
I am currently pregnant.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that project to muscles that control the legs and trunk in people with Parkinson's disease. The outcome variables will be further analyzed to understand their relationship to quant…
The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that project to muscles that control the legs and trunk in people with Parkinson's disease. The outcome variables will be further analyzed to understand their relationship to quantitative measures of postural instability and gait dysfunction. As such, the project can be classified as basic physiologic research. The protocol is not designed to determine if measures of corticocortical or corticofugal excitability can be used as a biomarker to predict disease progression.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
Participants with Parkinson's disease
* Diagnosis of idiopathic PD or dystonia as determined by a movement disorders neurologist in accordance with the UK Society Brain Bank diagnostic criteria.
* Age 45-80 years.
* Able to ambulate independently without the use of an assistive…
Inclusion Criteria:
Participants with Parkinson's disease
* Diagnosis of idiopathic PD or dystonia as determined by a movement disorders neurologist in accordance with the UK Society Brain Bank diagnostic criteria.
* Age 45-80 years.
* Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters.
Healthy Older Adults (Control participants)
* Age 45-80 years (this group will be age and sex-matched to the PD group)
* Able to ambulate independently without the use of an assistive device (cane or walker)
Healthy Young Adults
* Age 21-44 years (this group will be age and sex-matched to the PD group)
* Able to ambulate independently without the use of an assistive device (cane or walker)
Exclusion Criteria:
* Subjects who describe a history of a frequent vasovagal syncope (fainting) in response to blood, emotional stress, or sensory triggers.
* Subjects who are on anti-coagulant medications.
* Any musculoskeletal disorder that affects the ability to stand.
* History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury.
* Intracranial metallic or magnetic devices.
* Pacemaker or any implanted device.
* History of surgery on blood vessels, brain or heart.
* Unexplained, recurring headaches or concussion within the last six months.
* Moderate to severe hearing impairment.
* Subjects who are pregnant.
* Dementia diagnosis
* Other significant neurological disorders that may affect participation or performance in the study
* Implanted deep brain stimulator or other neurosurgeries to treat PD.
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